摘要
患者男，59岁，因全身结节、斑块伴疼痛3个月就诊。皮肤科检查：躯干、四肢可见多个浸润性红色斑块和结节，压痛明显。皮损组织病理检查：真皮和皮下单一淋巴样细胞弥漫性浸润，核深染，染色质细如粉尘。免疫表型：肿瘤细胞CD20、CD79a、CD10、TdT、PAX5弥漫阳性，Ki-67增殖指数为70％。骨髓检查：骨髓增生活跃，以淋巴细胞异常增生为主，原幼淋占66％。诊断：皮肤B淋巴母细胞性淋巴瘤／白血病，诊断后转肿瘤科治疗。
A 59-year-old man presented with a 3-month history of infiltrated aching nodules and plaques all over the body. Physical examination revealed multiple firm, erythematous nodules and plaques with marked tenderness on the trunk and limbs. Histopathological examination showed that there was a diffuse infiltrate of unique lymphoid cells with dark-stained nuclei and dust-like chromatin in the dermis and subdermis. Immunophenotype analysis showed that the tumor cells were diffusely positive for CD20, CD79a, CD10, terminal deoxynucleotidyl transferase （TdT）, PAXS, and for Ki-67 （70%）. Bone marrow examination revealed an active proliferation of bone marrow cells, which were predominated by lymphocytes, with lymphoblasts and prolymphocytes accounting for 66%. The patient was diagnosed with cutaneous precursor B- cell lymphoblastic lymphoma/leukemia.
出处
《国际皮肤性病学杂志》
2013年第1期4-6,共3页
International Journal of Dermatology and Venereology
