促血管生成因子在银屑病发病机制中的作用

Roles of angiogenic factors in the pathogenesis of psoriasis

微血管异常是银屑病组织病理学的显著特征，在银屑病发病机制中起着至关重要的作用。血管因子从作用机制上分为促血管生成因子和血管新生抑制因子，二者的平衡是维持血管稳定状态的关键。研究表明，银屑病皮损处角质形成细胞是血管生成因子的主要来源，血管生成因子有诱导血管增生的能力，而新生血管又为增生的角质形成细胞提供细胞和组织所需营养，并能促进炎症细胞迁移。探讨血管生成因子在银屑病中的作用将为临床治疗银屑病提供新思路。

Microvascular abnormalities, as a characteristic feature of psoriasis, play a crucial role in the pathogenesis of psoriasis. Vascular factors can be classified into angiogenic factors and angiogenic in- hibitors by action mechanisms, and the balance between them determines the stability of blood vessels. Studies have shown that keratinocytes in lesional skin are a major source of angiogenesis factor in psoriasis. Angiogen- esis factors have the ability to induce angiogenesis, and neovessels in turn provide nutrition to hyperplastic keratinocytes and promote migration of inflammatory cells. Exploring the role of angiogenesis factors in psoria- sis may provide new ideas for the treatment of psoriasis.