蜡球造孔法制备多孔HA陶瓷支架及其性能优化

Preparation and Optimization of Porous HA Ceramic Scaffolds by Wax Spheres Leaching Method

组织工程支架的贯通性对其体内生物学表现具有重要影响。采用甲壳素溶胶体系和蜡球造孔剂制备多孔羟基磷灰石(HA)陶瓷支架,考查在相同模压条件下,不同浆料/造孔剂比例对多孔HA陶瓷支架的孔隙率、收缩率、贯通性、多孔结构以及抗压强度的影响。结果表明:该方法可以制备具有高孔隙的多孔HA陶瓷支架,随着造孔剂比例的增大,支架的贯通性更好,当浆料/造孔剂比例为1:1.2时可以得到孔隙率、贯通性、力学性能最优的多孔HA陶瓷支架。

Interconnectivity of tissue engineering scaffolds plays a very important role in biological performance in vivo. In this work, chitin sol and wax spheres were used for preparing porous hydroxyapatite （HA） ceramics scaffolds by particle leaching and gel-casting methods. Under the same mounded casting condition, the effect of ratio of slurry/wax pore former on porosity, shrinkage, interconnectivity, porous structure and compressive strength were investigated systematically. Porous HA ceramic scaffolds were evaluated by gravimetric method, stereomicroscope, X-ray diffraction （XRD）, scanning electron microscope （SEM） and universal testing machine. The results show that the present method is an effective method to fabricate a highly porous HA ceramic scaffolds. With increasing the ratio of slurry/wax spheres, the interconnectivity gets better and the optimal ratio of slurry/wax spheres is 1：1.2.