超顺磁性磷酸钙复合支架的制备及性能研究

Preparation and Properties of Supermagnetic Calcium Phosphate Composite Scaffold

采用共混-真空烧结方法制备了一系列超顺磁性磷酸钙复合支架,通过SEM、EDS、XRD和VSM等手段对所制备的材料性能进行表征,并考察了其在水中的稳定性以及Ros17/2.8细胞在材料表面的黏附生长情况。结果表明:该方法所制备的超顺磁性复合支架具有多级连通孔结构,磁性纳米颗粒在基体中分布均匀,结合牢固且复合量精确可控,在水中具有良好的稳定性。真空烧结避免了磁性纳米颗粒在烧结过程中发生氧化和相变,使复合支架继续保持超顺磁性并具有良好的磁性能,且该磁性支架有利于细胞的黏附和生长,具有较好的生物相容性,在组织工程中有潜在的应用前景。

Supermagnetic calcium phosphate composite scaffold was fabricated by merging the superparamagnetic iron oxide （SPIO） into the calcium phosphate scaffold, and then sintered in vacuum. Properties of the obtained magnetic scaffold were investigated by SEM, EDS, XRD and VSM, The stability of magnetic scaffold in water was assessed and Ros17/2.8 cells were cultured on the samples to evaluate the cell adhesion on the scaffold. The results demonstrated that the magnetic scaffold had a porous structure. The magnetic nanoparticles were uniformly distributed and firmly merged into the matrix. The content of magnetic nanoparticles could be accurately tuned, and the magnetic scaffold is stable in water. The composite scaffold maintained excellent magnetic properties, as the vacuum sintering procedure avoided the oxidation and phase transition of the magnetic nanoparticles. It is proposed that the magnetic materials might be a kind of potential bone tissue engineering scaffold in the future.