淋巴瘤样丘疹病1例

Lymphomatoid Papulosis: A Case Report with Literature Review on Therapy

患者男,27岁。躯干、四肢反复发生暗红色丘疹、结节、坏死、结痂4月余,无痛,偶有瘙痒。皮肤科情况:躯干、臀部及四肢暗红色丘疹、结节,部分中央坏死、破溃,结黑褐色厚痂,留有萎缩性瘢痕或色素沉着。皮损组织病理示:真皮结节状淋巴及大组织样细胞浸润,可见多数异型细胞,约占30%,少数细胞呈双核或多核;免疫组化染色示:CD3(+),CD4(+),CD30(+),CD68(+),CD8个别(+),CD20个别(+),Ki-67约10%(+)。诊断:淋巴瘤样丘疹病。

A 27-year-old male presented with recto＇rent dark red papules, nodules, mecrosis and eruss on the trunk, bultocks, arms and legs more than 4 months before. Physical examination revealed dark red papuh＇s, nodules on the trunk, bullocks and extremities. Some lesions were centrally necrotic, ulcerated with dark brown lhick crusts and alrophic scars or pigmentation, ttistopathologically, there were nodular lymphoid cells and large histiocytoid cells （about 30% ） infiltrale in dermis. Some were atypical with dual-core or muhicore morphnlngy. Immunohislochemically, they were diffusely positive for CD30, CD8, CD20, densely posilive for CD3, CD4, CD68. Abnut 10% cells were positive for Ki-67. A diagnosis of lymphonmtoid papulnsis was made.