龙津降纤酶治疗急性缺血性卒中临床疗效观察

Clinical Observations on Therapeutic Effect by the Use of Longjin Difibrase to Treat Acute Ischemic Cerebral Apoplexy

目的 观察龙津降纤酶对急性缺血性卒中的治疗效果。 方法 选择诊断明确的急性缺血性卒中病人 80例 ,随机分为 2组 :对照组 4 0例 ,5%葡萄糖液 50 0 ml加血塞通注射液 0 .4 g静脉滴注 ,连用 1 4天 ;降纤酶组 4 0例 ,入院后第 1～ 3天分别给降纤酶 1 0 u加入生理盐水 1 0 0 ml,静脉滴注 1 h以上 ,按临床神经功能缺失程度评分标准于治疗前及治疗后 1 4天进行疗效评定。 结果 降纤酶组总有效率达 92 .5%,显效率为 72 .5%,明显优于对照组 ( 67.5%,3 7.5%) ,并可显著降低血纤维蛋白原 ,而对血小板计数、出、凝血时间、凝血酶原时间无明显影响 ,治疗中未见明显不良反应。 结论 龙津降纤酶对急性缺血性卒中治疗有效、安全。

Objective Therapeutic effect of Longjin Difibrase on acute ischemic cerebral apoplexy is observed Method 80 cases of acute ischemic cerebral apoplexy who were given confirmed diagnosis were randomly divided into two groups;40 patients served as the control group who were given intravenous drip with 500ml glucose saline plus 0 4g Xuesetong injuction for successive 15 days 40 cases(Difibrase-treatment group) were given difibrase 1 Ou plus 100ml normal saline for over 1 hour on the 1~3 days after admission According to the standard of the clinical nervous function and defect degree,we judged the curative effect on the fourteen day before and after treatment Result In the difibrase-treatment group the overall effective rate amounted to 92 5%; marked effective rate 72 5%, which is superior to the effective rate in the control group(67 5%,37 5%) It can obvionsly decrease fibrinogenemia,and there is no apparence influence on the platelet count bleeding-clotting time and prothrombin times During treatment there was no untoward reaction Conclusion Poplexy longjin difibrase is effective and safe in the treatment of acute ischemic cerebral