降纤酶治疗急性脑梗死血浆D-二聚体的研究

Study on Effects of Plasma D-dimer on Treatment of Acute Cerebral Infarction by Difibrase

目的 探讨降纤酶治疗急性脑梗死患者血浆 D-二聚体水平的变化以证实其溶栓作用。 方法 采用前瞻性、随机、双盲对照方法。将 70例急性脑梗死病人分为治疗组和对照组 ,分别于治疗前和治疗后第 6天测血浆纤维蛋白原和 D-二聚体。 结果 治疗组血浆纤维蛋白原治疗后比治疗前有明显下降 ,两者比较有明显的差异 ( P <0 .0 1 )。血浆 D-二聚体治疗后比治疗前有明显的增高 ,两者比较有明显的差异 ( P<0 .0 1 )。而对照组均无明显差异 ( P >0 .0 5)。 结论 降纤酶通过诱发体内 t-PA释放和增强 t-PA活性而产生明显的溶栓作用。

Objectove Purpose to investigate therapy effects of difibrase on serum D dimer changes of patients with acute cerebral infarction so that to prove its dissolution thrombus effects Methods To cases of acute cerebral infarction patients were randomly devided in to control group and therapy group plasma fibrinogen and D dimer were detected before therapy and sixth day after therapy respectively Results There was a significant drop of plasma fibrinogen after therapy compared with cases before therapy(P<0 01) D dimer of plasma was also marked increased after therapy(P<0 01) while control group did not reach statisfical significance after and before therapy(P<0 05) Conclusion The significant dissolution thrombus effects of difibrase is by inducing t-PA release and enhancement of t PA activity