局部应用前列腺素类药物对中央角膜厚度改变的影响被引量：5

Effect on central corneal thickness after use of three prostaglandins

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摘要目的:分析曲伏前列素、拉坦前列素和贝美前列素用药后对中央角膜厚度的影响。方法:采用回顾性临床病例对照研究,60例68眼随机分为3组,其中曲伏前列素组20例22眼,拉坦前列素组20例25眼,贝美前列素组20例21眼。测量用药前及用药6mo后的中央角膜厚度。结果:三组用药后平均中央角膜厚度与用药前比较均明显变薄,曲伏前列素组从525±36.45μm下降至510±27.87μm(t=8.11,P<0.05),拉坦前列素组从530±26.65μm下降至512±22.27μm(t=5.62,P<0.05),贝美前列素组从534±47.35μm下降至516±19.56μm(t=5.62,P<0.05)。用药后6mo,三组间平均中央角膜厚度比较无明显差别(F=0.205,P=0.544)。结论:局部应用前列腺素类药物可以使中央角膜厚度变薄。 AIM：To compare the effect on central coreal thickness（CCT） after using Travoprost,Latanoprost and bimatoprost.METHODS：By clinical retrospective case control study,patients with primary open angle glaucoma（POAG） were randomly classified for 3 groups：Twenty patients（22 eyes） were treated with Travoprost,20 patients（25 eyes） were treated with Latanoprost,and 20 patients（21 eyes） were treated with bimatoprost.CCT before and 6 months after the treatments was observed.RESULTS：The CCT of 3 groups had decreased markedly after 6 months.Travoprost group decreased from 525±36.45μm to 510±27.87μm（t=8.11,P=0.001）,Latanoprost decreased from 30±26.65μm to 512±22.27μm（t=7.34,P=0.001）,and Bimatoprost reduced from 534±47.35μm to 516±19.56μm（t=5.62,P=0.001）.The effectiveness of the treatments did not differ significantly when the three groups were compared（F=0.205,P=0.544）.CONCLUSION：The study demonstrated that use of prostaglandins could reduce the CCT.

作者华佩炎宣懿

机构地区上海交通大学医学院附属新华医院眼科复旦大学附属眼耳鼻喉科医院眼科

出处《国际眼科杂志》 CAS 2013年第1期159-160,共2页 International Eye Science

关键词前列腺素类药物青光眼中央角膜厚度 prostaglandins glaucoma central corneal thickness

分类号 R775 [医药卫生—眼科]

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参考文献16

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二级参考文献6

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