摘要
In this study,the DNA logic computing model is established based on the methods of DNA self-assembly and strand branch migration.By adding the signal strands,the preprogrammed signals are released with the disintegrating of initial assembly structures.Then,the computing results are able to be detected by gel electrophoresis.The whole process is controlled automatically and parallely,even triggered by the mixture of input signals.In addition,the conception of single polar and bipolar is introduced into system designing,which leads to synchronization and modularization.Recognizing the specific signal DNA strands,the computing model gives all correct results by gel experiment.
In this study, the DNA logic computing model is established based on the methods of DNA self-assembly and strand branch migration. By adding the signal strands, the preprogrammed signals are released with the disintegrating of initial assembly structures Then, the computing results are able to be detected by gel electrophoresis. The whole process is controlled automatically and parallely, even triggered by the mixture of input signals. In addition, the conception of single polar and bipolar is introduced into system designing, which leads to synchronization and modularization. Recognizing the specific signal DNA strands, the computing model gives all correct results by gel experiment.
基金
supported by the National Natural Science Foundation of China (61127005,61133010,61033003,60910002 and 61143003)
Ph.D.Programs Foundation of the Ministry of Education of China (20110001130016)
the Postdoctoral Special and Normal Science Foundation of China(201104018,20100480128,2011M500197)
关键词
DNA链
运算模型
自组装
逻辑
迁移
输入信号
分子
凝胶电泳
DNA strand branch migration, DNA self-assembly, molecular logic computing, molecular intelligence, modularized design
