摘要
Estrogen exerts its biological effects through two signal pathways,the genomic and non-genomic pathway,both of which contribute to cell homeostasis.The non-genomic pathway has been suggested to be important in estrogen-induced cardio-,neuron-,and osteoprotection,and confers the ability of the cell to rapidly respond to its environment.The effects of the non-genomic pathway are the regulation of different cellular processes,such as proliferation,survival,apoptosis,and other functions in diverse cell-types.The proline-,glutamic acid-,and leucine-rich protein 1(PELP1),is now known as a modulator of the estrogen receptors,and is also a novel coregulator of the non-genomic signal pathway with various functions.Therefore,the evaluation of the molecular crosstalk between PELP1 and the non-genomic pathway may lead to the development of functionally selective estrogen receptor modulators which can participate in the multiple functions of estrogen signaling in reproductive tissues and other organs.
Estrogen exerts its biological effects through two signal pathways, the genomic and non-genomic pathway, both of which contrib-ute to cell homeostasis. The non-genomic pathway has been suggested to be important in estrogen-induced cardio-, neuron-, and osteoprotection, and confers the ability of the cell to rapidly respond to its environment. The effects of the non-genomic pathway are the regulation of different cellular processes, such as proliferation, survival, apoptosis, and other functions in diverse cell-types. The proline-, glutamic acid-, and leucine-rich protein 1 （PELP1）, is now known as a modulator of the estrogen receptors, and is also a novel coregulator of the non-genomic signal pathway with various functions. Therefore, the evaluation of the molecular crosstalk between PELP1 and the non-genomic pathway may lead to the development of functionally selective estrogen receptor modulators which can participate in the multiple functions of estrogen signaling in reproductive tissues and other organs.
