细胞内信号分子传导的研究进展

Progress in the Studies of Intracellular Signal Transduction

近年来有关细胞内信号传导的研究,着重体现在Ca2+信号传导途径及相应的蛋白质分子如蛋白激酶C(PKC)、钙调素(CaM)、钙调素激酶Ⅱ(CaMKⅡ),同时也对Ras途径中出现的Vav、Rap、Crk、C3G等蛋白质分子以及cAMP和NFκB途径作了有益的补充与修改.细胞外信号分子通过以上4种途径及其相互通讯(crosstalk),激活了某些蛋白激酶,调控了基因转录及其他相关功能。

The latest development on intracellular signal transduction mainly focus on Ca 2+ pathways with their related protein molecules such as PKC,CaM,CaMKⅡ,and Ras with their related protein molecules(such as Vav,Rap,Crk,C3G),cAMP,NF κB pathways as well. Through the above mentioned four pathways and the cross talk among them,extracellular signal molecules activate some protein kinases which regulate gene transcription and other related functions.It should be noted that phosphorylation plays a significant role in regulating the activity of protein kinases and transcript factors.