摘要
以分子对接(docking)方法研究人白介素6受体胞外区配基结合功能域“WSXWS”区氨基酸残基定点突变对受体与配基人白介素6结合时的相互作用能量、分子间相互作用的影响,从分子力学、分子动态学分析了人白介素6受体胞外区功能域关键氨基酸残基在受体与配基结合中的构象变化以及与人白介素6间的相互作用.
Based on molecular docking method, the influence of interaction energy and molecular interaction between mutated ligand combining functional domain “WSXWS” of human interleukin 6 receptor(hIL 6R) and human interleukin 6(hIL 6) is studied. The conformation changes on key amino acids of human interleukin 6 receptor when combining with human interleukin 6 and the interactions between human interleukin 6 receptor and human interleukin 6 are analyzed.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
2000年第1期53-57,共5页
Progress In Biochemistry and Biophysics
基金
国家自然科学基金!资助项目 (39480 0 2 5)
关键词
人白介素6
受体
分子对接
WSXWS
构效关系
human interleukin 6 receptor(hIL 6R), human interleukin 6(hIL 6), molecular docking , functional domain
