碳酸钙的磷酸盐溶液浸泡法合成磷灰石人工骨

Fabrication of Apatite by Soaking Calcium Carbonate in Phosphate Solution as Bone Substitute

目的:采用溶液浸泡法将碳酸钙转化成磷灰石,并测试其理化性能。方法:将通过Ca(OH)2的碳酸化生成的Ca-CO3浸泡在60℃、1 mol/L磷酸二氢钾盐溶液中1～14 d,借助X射线衍射分析(XRD)、红外吸收光谱测定(FTIR)、抗张强度(DTS)测试、钙磷比分析、碳酸含量测定、扫描电子显微镜(SEM)等分析手段对各样本的形貌、机械性能及组成进行了研究。结果:XRD、FT-IR、SEM结果均显示经过14 d处理,CaCO3已完全转化成为B型碳酸磷灰石,其抗拉强度(5.75±0.30)MPa,作为骨缺损重建材料的机械强度是足够的。化学元素分析结果显示生成的碳酸磷灰石的钙磷比与碳酸含量均高于骨。结论:本方法是在低温低压下即能合成具有优良机械性能的低结晶性碳酸磷灰石团块的简单可行的方法。

Objective： To convert calcium carbonate into apatite by treatment with a phosphate solution and test its properties. Methods： Calcium carbonate monolith prepared by carbonation of Ca （OH）2 monolith was treated in 1 mol/L potassium dihydrogen phosphate solutions at 60 ℃. The morphology, mechanical properties and composition of the apatite were characterized by X-ray dif- fraction （XRD）, Fourier- transform infrared spectroscopy （F-FIR）, Diametral tensile strength （DTS） test, carbonate content, Ca/P molar ratio and scanning electron microscopy （SEM）. Results： The results of XRD, FTIR spectroscopy studies and SEM observation showed that calcium carbonate completely transformed into B-type carbonate apatite after treated for 14 days. DTS results showed that the DTS value was （5.75 ±0. 30） MPa for 14 days, which has adequate mechanical strength as a reconstruction materials for bone defect. Chemical analyses showed molar Ca/P ratios and carbonate contents were higher than those of bone. Conclusions： The pres- ent method allows an easy fabrication of low-crystalline B-type carbonate apatite monolith with adequate strength in low temperature and low pressure.