几种含1,3,4-噁二唑基团的3(2H)-哒嗪酮化合物的合成

Synthesis of Several 1,3,4-oxadiazole group pyridazin-3(2H)-one compounds

双杂环类化合物是药物研究的重要方向之一,在分子中同时引入两个或多个杂环活性中心,能改善化合物的生物活性,从而得到应用价值更高的化合物。本文以酯为原料,经肼解、闭环、取代等步骤成功地在哒嗪酮中间体的侧链导入1,3,4-噁二唑基团,合成了7种未见文献报道的含有哒嗪环和噁二唑环的双杂环化合物。所有化合物均经1H NMR、13C NMR和元素分析对其结构进行了表征。

Double heterocyelic compounds is one of the most important direction in drug research, molecular at the same time introduce two or more heterocyelie activity center, can improve the biological activity compounds, so as to get the application value higher compounds. This article by ester as raw material, Synthesis of 7 new compounds were opti- mized. All the synthesized compounds were characterized by elemental analysis, IR, 1H -NMR and 1~C -NMR spectra Moreover.