氧化铝催化7-表-紫杉醇转化为紫杉醇的机理探索

Studies of the Mechanism of 7-epi-taxol Converted to Taxol from Taxus Extract Catalyzed with Al_2O_3

在碱性氧化铝作用下 ,云南红豆杉浸膏中 7 表 紫杉醇被催化转化为紫杉醇。该异构化反应是由氧化铝表面L酸中心、碱中心的协同作用而催化 ,在室温条件下就可进行 ,氧化铝表面酸碱中心的种类和强度都将影响反应进行的程度 。

Under the catalysis of Al 2O 3,7 epi taxol in Taxus yunnanensis extract could convert to taxol.The factors including the concentration of CH 3OH in the mobile phase,the type of Al 2O 3 and the reaction time could influence the isomeric reaction.The catalysis mechanism fo Al 2O 3 was investigated.The isomerization of 7 epi taxol was under the cooperation of the Lewis souci activity core and the basic activity core in the surface of Al 2O 3 at room temperature.The type and strength of activity core controlled the procedure of reaction,and the suitable content of CH 3OH in the mobile phase would accelerate the reaction.