中国丙型肝炎病毒基因型分布

Hepatitis C virus genotypes in China： a systematic review

目的分析中国丙型肝炎病毒（HCV）基因型的分布及变化趋势。方法计算机检索1994年以来中国医院知识库（CHKD）、1998年以来万方数据资源系统、中周生物医学文献数据库（CBMDisc）以及PubMed数据库，并结合文献追溯方法，收集国内HCV基因分型的相关文献。相同HCV亚型分别按地区、研究时间、人群分组，并进行简单数量合并，计算百分比。结果共纳入文献140篇（共168条记录）。不同地区HCV基因型存在差异，其中北方地区基因型较单一，以1b和2a型为主；南方地区HCV基因型种类较多，以1b型为主，2a、3a、3b及6a型各自占较大比例。早期HCV基因型较单一，随着时间推移，1b及2a亚型逐渐减少，而3a、3b及6a亚型逐年增加，亚型类型逐年增多。有偿献血人群1b、2a亚型所占比例较高；吸毒人群HCV基因亚型较多，3型（3a、3b亚型）及6a亚型所占比例较大，且有逐渐向普通人群扩散趋势。结论中国流行最广泛的HCV基闪亚型为1b及2a，且分布地区差异较大，并随时间的推移，基因型分布产生较大变化。

Objective To provide information on the geographical distribution of hepatitis C virus （HCV） genotype and subtypes in the Chinese population. Methods A comprehensive search was carried out in CHKD （China Hospital Knowledge Database）, Wanfang （Chinese）, CBMDisc and PubMed databases to identify all the papers being published on HCV genotypes/serotypes and subtypes in China. All studies were grouped according to the sites,period and objects of the studies, to analyse the distribution of HCV genotype. Results A total of 140 studies were included in this Meta-analysis program, which contained 168 records. We found that the predominate genotypes in China were I b and 2a subtype, and the distributions of HCV subtypes were different in the western or southern parts of the country. Subtypes 3a, 3b and 6a had been significantly increased along with the decrease of subtypes lb and 2a. There were various HCV subtypes among injection drug users with subtypes 3a, 3b and 6a found among them. Conclusion The distribution of HCV genotypes and subtypes in the Chinese population had changed significantly.