摘要
目的研究脉血康胶囊(水蛭)对高脂血症大鼠脂质代谢及黏附分子表达的影响及其可能机制。方法将50只健康雄性SD大鼠随机分为正常对照组、模型组、脉血康高、中、低剂量组。采用高脂饮食法建立大鼠高脂血症模型,治疗组在高脂饮食的基础上每天给予相应的药物,连续喂养8周。检测血脂[总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)]、血糖(Glu)、血清一氧化氮(NO)、血浆纤维蛋白原(FIB),用ELISA法检测主动脉壁细胞间黏附分子-1(ICAM-1)的表达。结果与模型组相比,脉血康胶囊可以明显降低Glu、TC、TG、LDL-C,升高NO、HDL-C(P<0.05);动脉粥样硬化指数(AI)和血浆FIB有降低趋势;ICAM-1的表达明显减弱(P<0.05)。结论脉血康胶囊通过调节脂质代谢、纠正NO代谢紊乱及抑制ICAM-1的表达等环节,干预动脉粥样硬化的形成。
AIM To study the influence and possible mechanism of Maixuekang Capsules （Hirudo） on lipid metabolism and expression of adhesion molecule in rats with hyperlipidemia. METHODS Fifty healthy male SD rats were randomly divided into five groups ： normal control group, model control group, and high, middle, low dose groups of Maixuekang Capsules. The hyperlipidemia model was established by feeding rats with high fat diet, and corresponding medicines were administrated on the basis of high fat diet for eight successive weeks. Levels of blood lipid, blood glucose （Glu）, nitric oxide （NO）, plasma fibrinogen （FIB） were observed. The expression of intercellular adhesion molecule 1 （ ICAM-1 ） in aortic wall was detected by ELISA. RESULTS Compared with the model control group, Maixuekang Capsules could decrease the levels of Glu, total cholesterol （ TC）, triglyceride （TG）, low density lipoprotein cholesterol （LDL-C） and increase the levels of NO, high density lipoprotein cholesterol （HDL-C） （P 〈 0. 05 ）. Atherogenic index （AI） and FIB decreased. The expression of ICAM-1 was attenuated in all the treatment groups （P 〈 0. 05 ）. CONCLUSION Maixuekang Capsules can inhibit atheroscle- rosis by modulating the lipid metabolism, improving NO metabolic disorder and inhibiting the expression of ICAM-1.
出处
《中成药》
CAS
CSCD
北大核心
2013年第1期1-5,共5页
Chinese Traditional Patent Medicine
基金
天津市中医药管理局中医
中西医结合资助课题(11102)
