益气化瘀药对系膜增生性肾小球肾炎大鼠肾组织PDGF-B表达影响的概述

Effects of Yiqi Huayu Recipe on Expression of PDGF-B in Rats with Mesangial Proliferative Glomerulonephritis

系膜增生性肾炎(mesangial proliferative glomerulonephritis,MsPGN)是一组病理上以弥漫性肾小球系膜细胞(MC)增生、肾小球基底膜(GBM)增厚及不同程度肾小球系膜区细胞外基质(ECM)积聚为主要特征的肾小球疾病。MsPGN为我国原发性肾小球疾病中最常见的病理类型,国内资料显示该型约占原发性肾小球疾病肾活检病例的20.3%～24.7%。若未采取有效治疗,最终导致不可逆性肾小球硬化。中药治疗MsPGN具有较好疗效,并且可以减少复发,其中益气化瘀之品黄芪、水蛭是最常用的治疗药物。传统认为MsPGN以气虚等本虚为本,血瘀等邪实为标,但临床上血瘀似乎占有更重要的地位,活血化瘀几乎是治疗MsPGN的基本方法。

Mesangial proliferative glomerulonephritis is a glomerular disease with the main feature of glomerular MC prolifera- tion, GBM and ECM accumulation. MsPGN is the most common pathological type of primary glomerular disease. The domestic data shows 20.3% to 24.7% of the cases of this type accounting for primary glomerular disease by renal biopsy. And it will eventually lead to irreversible glomerulosclerosis without effective treatment. Chinese medicine, espacially Radix Astragali and Hirudo do have a good effect on MsPGN and can reduce the recurrence. The traditional Chinese medicine views the blood stasis is the real e- vil and qi deficiency is the root of MsPGN but stasis seems to occupy an important position in clinic, and promoting blood circula- tion is almost the basic treatment on MsPGN.