卡肌宁在复合麻醉应用中的效应观察

Observation of Therapeutic Effect of Atracurium Applied to Compound Anesthesia

卡肌宁是一种新型中效非去极化神经肌肉松弛剂。本文通过17例临床应用,对卡肌宁作用期间肌松效应、血气及拔管时病人的表现3个方面进行了初步观察。卡肌宁肌松效应平均显效时间1.40±0.75min,维持时间为30.31±6.76min,恢复时间为58.53±17.21min。从这些资料看出卡肌宁作用为中效,显效快、无蓄积。此外,观察呼吸变化及拔管时的表现,作者认为除指导和平衡血中卡肌宁刺量外,也可作为对卡肌宁作用期效应监测的一种指标。

Atracurium(ATC)is a new drug for the neuromuscular relaxation with a desirable effect and nondepolarization action. During action stage the muscular relex, blood gas analysis and manifestation right after extraction of intubation were closely watched. The effective time o ATC was 1.40±0.75 rain in average, and the maintaining time 30.31±6.76 min. The effect disappeared in 58.53±17.21min. From these materials, ATC provided a moderate action. It developed rapidly without any accumulation of side effect. Beside the authors devoted that the observation of respiration change and appearenee duringde-intubation might guide the dosage of ATC for balance and also be used as an indicator for long-time monitoring.