350例新生儿巨细胞病毒感染现状调查与分析

The survey analysis of the cytomegalovirus infection for 350 newborns

目的:探讨新生儿巨细胞病毒(CMV)感染的影响因素并提出预防措施。方法:对350例孕母脐带血巨细胞病毒抗体及新生儿尿巨细胞病毒DNA检测并收集相关信息进行统计学分析。结果:孕母脐带血抗体阳性的新生儿CMV-DNA感染率较高,达21.62%(P<0.01),并且IgM抗体阳性比IgG抗体阳性的更为显著(Fisher概率确切法P<0.05)。结论:新生儿CMV-DNA感染存在明显的母婴垂直传播现象,近期感染的孕母传播率更高,应着重加强对孕母孕前的诊断治疗和落实孕期的预防措施。

Objective： To study the influential factors of the newborns human cytomegalovirus infective and put forward the preven- tive measures. Methods： To screen the cord blood eytomegalovirus antibodies of 350 pregnancies and the neonatal urine cytomegalovirus DNA, then the related information was collected and analyzed by the statistical methods. Results： The CMV - DNA infective rates （21.62%） of the newborns whose mothers had a positive cord blood antibody were higher, and the positive of lgM antibody was more marked than the single positive of IgG antibody （ P 〈 0.05 ） . Conclusion ： The neonatal CMV - DNA infection has a obvious vertical transmission, there is a higher spread rate from the recent infective pregnancies. We should strengthen the pregnant diagnosis and treatment and carry out the pregnancy prevention measures.