川芎嗪佐治新生儿硬肿症疗效观察

Efficacy on the Assisting Treatment of Ligustrazine in Sclerema Neonatorum

将新生儿硬肿症随机分成两组,对照组33例给予复温、补液、加强喂养以及激素、抗生素、维生素E等治疗;治疗组31例在对照组治疗的基础上加用川芎嗪2～4mg/kg·d^(-1),分1～2次静脉滴注,直至硬肿消失。结果两组复温所需时间无明显差异,硬肿开始消退时间治疗组为2.5±0.95d,对照组5.88±2.82d,两组间差异有显著性(P<0.01);硬肿完全消失的时间,治疗组为6.89±2.27d,对照组11.63±3.88d,两者差异有显著性(P<0.01)。笔者对川芎嗪作用机理及优点进行了讨论。

Sclerema neonatorum was divided into 2 groups randomly. Thirty three cases of control group were given warm for recovery, fluid, forced feeding, hormone, antibiotic and vitamine E. Thirty one cases of therapeutic group were given Ligustrazine 2-4 mg/kg.d^(-1) on basis of same therapy as control group and dropped into vein until scleroderma disappeared. There was no significant difference in time required for recovery to normal temperature in the 2 groups. Times required for scleroderma began to disappear in therapeutic group and control group were 2.5±2.95d and 5.88±2.82d respectively(P<0.01). Times that required for scleroderma to disappear completely, in therapeutic group and control group were 6.89±2.27 d, and 11.63±3.88 d respectively(P<0.01). Significant differences were showed in both. Functional mechanism and advantantages of Ligustrazine werediscussed.