中药单体对脑缺血再灌注损伤保护的实验研究进展

Experimental Research Progress on Chinese Medicine Monome Protection of Cerebral Ischemia Reperfusion Injury

中医药在对脑缺血再灌注损伤的干预方面具有多靶点、多向调节的作用。文章从脑缺血再灌注后神经元超微结构变化、脑血流量改变、钙离子超载、炎症反应、兴奋性氨基酸神经毒性、一氧化氮脑神经毒性和保护作用、自由基损伤和氧化作用及神经元凋亡相关基因的表达八个方面,就近几年中药单体对脑缺血再灌注损伤干预的实验研究现状予以综述,并对存在的问题进行讨论。

The intervention of traditional Chinese medicine（TCM） to cerebral ischemia reperfusion injury（ICRI） has many actions of targets and directions.In this review,we summarized the experimental research progress on Chinese medicine monomer protection of CIRI,after cerebral ischemia and reperfusion,from the following eight aspects such as changes of neurons ultrastructural,changes of cerebral blood flow,calcium overload,inflammation,neurotoxicity of excitability amino acids,cranial nerve toxicity and protection of nitric oxide,free radical damage and oxidation,gene expression of apoptosis neurons,and discussed the existing problems in experimental research.