fat-1转基因动物研究进展

Advances in fat-1 Transgenic Animals

转染秀丽隐杆线虫fat-1基因后的哺乳动物具备了将n-6多不饱和脂肪酸(PUFAs)转化为n-3 PUFAs的能力,可降低动物机体的n-6/n-3 PUFAs比例。n-3 PUFAs有益于人类健康,可减少多种相关疾病发生的风险,但人体内不能合成n-3 PUFAs,其必须依赖于富含n-3 PUFAs的食品,fat-1转基因动物将成为人类必需的n-3 PUFAs的重要来源。对fat-1及其转基因动物的研究现状进行综述。

Mammals engineered by fat-1 gene from Caenorhabditis elegans can convert n-6 polyunsaturated fatty acids （ PUFAs ） to n-3 PUFAs, and decrease the ratio of n-f/n-3 PUFAs in vivo. Although n-3 polyunsaturated fatty acids have been shown to play an important role in health, and can reduce the risk of many diseases, humans can not synthesize the n-3 PUFAs automatically. This review summarized the status of research about fat-1 gene and fat-1 transgenic animals.