宣白承气汤加味联合铂类化疗治疗中晚期非小细胞肺癌痰热蕴肺证的临床观察

Clinical observations of effects of modified Xuanbaichengqi decoction combined with platinum-based chemotherapy on lung phlegm-heat accumulation syndrome in patients with advanced non-small cell lung cancer

目的观察宣白承气汤加味联合铂类化疗治疗中晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)痰热蕴肺证的疗效。方法收治中晚期NSCLC痰热蕴肺证患者40例,随机分为两组。治疗组20例给予宣白承气汤加味口服联合含铂类方案化疗,对照组20例给予单纯含铂类方案化疗。连续观察2个周期,比较治疗前、后两组瘤体大小及变化、临床主要症状评分、Karnofsky体力状况评分及毒副反应等情况。结果治疗组的临床疗效明显优于对照组,在瘤体大小及变化方面,治疗组的瘤体稳定率明显高于对照组(P<0.05),但两组有效率的差异无统计学意义(P>0.05);治疗组的临床症状改善情况、生活质量的提高及卡氏评分均显著高于对照组(P<0.05),治疗组毒副反应明显少于对照组(P<0.05)。结论宣白承气汤加味联合含铂类方案化疗治疗中晚期NSCLC痰热蕴肺证,可控制瘤体生长,改善患者临床症状,提高生活质量,减轻化疗毒副反应。中医"宣肺通腑,肺肠同治"法联合化疗治疗中晚期NSCLC痰热蕴肺证具有一定增效、减毒的作用。

Objective To observe the therapeutic effects of modified Xuanbaichengqi decoction combined with platinum-based chemotherapy on lungphlegm-heataccumulation syndrome in patients with advanced non-smal cell lung cancer （NSCLC）. Methods Forty patients with advanced NSCLC were divided randomly into a treatment group and control group.The treatment group received modified Xuanbaichengqi decoction combined with platinum-based chemotherapy,while the control group received only platinum-based chemotherapy.Clinical effects were observed over two treatment courses.Changes in tumor size, clinical symptoms, Karnofsky physical performance grade and side effects were evaluated. Results The treatment group showed significantly better tumor stabilization, improvement of clinical symptoms, quality of life and Karnofsky physical performance than did the control group （all P〈0.05 ）.In addition, the treatment group showed significantly fewer side effects（P〈0.05 ）. Conclusions Modified Xuanbaichengqi decoction combined with platinum-based chemotherapy is effective at controlling tumor growth, improving clinical symptoms and quality of life, and reducing chemotherapy side effects in the treatment of lung phlegm-heat accumulation syndrome in patients with advanced NSCLC.