生长期毛发松动综合征二例毛发形态学观察

Morphological observation of hairs in two patients with loose anagen hair syndrome

目的探讨2例生长期毛发松动综合征患者毛发形态。方法普通显微镜、扫描电镜、透射电镜观察患者的毛干及毛蜒。结果光学显微镜下见毛球变形，发干扭曲、损伤、断裂．远端明湿尖细，扣描电镜下弛患符毛球变形扭曲，毛护膜边缘呈波浪状等。透射电镜下见病变主要在内毛根鞘，内外毛根鞘细胞均见多数空泡化改变．细胞间黏附减低，桥粒结构减少或消失等。结论生长期毛发松动综合征患者病变主要在内毛根鞘。

Objective To observe the morphological changes of hairs in two patients with loose anagen hair syndrome. Methods Light microseopy, scanning eleetrom mieroseopy and transmission eleetron microscopy were used to observe the morphology of hair shaft and follicles fi＇om two patients, including a 3-year-old girl ehihl and her mother, with loose anagen hair swldrome. Results Light microscopy revealed tirol hair bulb was de- formed, hair shaft was distorted, damaged, and even disrupted, and hairs tapered in diameter at their distal end. Seanning electron microseopy showed defiwmed or dislorted hair shaft and wave-like edge of hair et, tieles. Transmission eleciron mieroscop.x revealed that pathological changes were mainly localized in the inner root sheath with vaetmlizalion in both inner and outer root sheath cells. Intercellular adhesion was weak with a decrease or disap- pearance of desmosomes. Conclusion The pathological changes of hairs are mainly localized in the inner root sheath in patients with loose anagen hair syndrome.