卵巢早衰危险因素的Meta分析

Meta-analysis of Risk Factors of Premature Ovarian Failure

目的:探讨卵巢早衰(premature ovarian failure,POF)的危险因素,为该病的防治提供依据。方法:运用Meta分析对国内、外发表的11篇关于POF的病例对照研究资料进行定量综合分析;采用Stata11.0软件对所选的因素进行异质性检验、合并OR值及95%CI。结果:与POF有关的因素主要包括遗传因素(家族史);医源性因素(盆腔手术史、腹部及盆腔X线照射);感染因素(腮腺炎病史);饮食生活习惯(吸烟、饮酒、经常食用蔬菜、经常食用豆制品、染发);心理因素(心情);月经、婚育史(月经初潮早、离异或丧偶、口服避孕药、人工流产次数)。各因素合并OR值及95%CI分别为吸烟1.97(1.56,2.48)、盆腔手术史3.88(2.77,5.42)、腮腺炎病史8.77(1.62,47.40)、离异或丧偶2.15(1.07,4.32)、经常食用蔬菜0.54(0.42,0.70)、饮酒2.19(1.36,3.55)、人工流产次数1.52(1.23,1.89)、经常食用豆制品0.65(0.25,1.66)、心情0.16(0.11,0.24)、口服避孕药2.47(0.97,6.27)、月经初潮早1.38(0.59,3.21)、家族史4.46(1.89,10.53)、腹部及盆腔X线照射2.92(1.88,4.54)、染发3.56(2.01,6.31)。结论:经常食用蔬菜和心情好是卵巢早衰的保护因素;经常食用豆制品、口服避孕药及月经初潮早与POF的关联无统计学意义;其余均为危险因素。

Objective： To explore risk factors of premature ovarian failure （POF）, and provide the basis for the prevention and treatment of the disease. Methods： Eleven case-control studies about risk factors of POF at home and abroad were comprehensively analyzed by Meta-analysis. And statistical analysis was performed using Stata 11.0 software. Results： Related factors with POF were genetic factor （family history）, latrogenic factor （pelvic surgery history, abdominal and pelvic X-ray exposure history）, infectious factor （mumps）, dietary and habits （smoking, drinking, regular consumption of vegetables, regular consumption of soy products, dye hair）, psychological factor （moods）, menstrual and obstetrical history （early menarche, divorce or widow, oral Contraceptives, the number of abortion）. The Pooled OR values （95%CI） of related factors were smoking 1.97 （1.56, 2.48）, pelvic surgery history 3.88 （2.77, 5.42）, mumps 8.77 （1.62, 47.40）, divorce or widow 2.15 （1.07, 4.32）, regular consumption of vegetables 0.54 （0.42, 0.70）, drinking 2.19 （1.36, 3.55）, the number of abortion 1.52 （1.23, 1.89）, regular consumption of soy products 0.65 （0.25, 1.66）, mood 0.16 （0.11, 0.24）, oral contraceptives 2.47 （0.97, 6.27）, early menarche 1.38 （0.59, 3.21）, family history 4.46 （1.89, 10.53）, abdominal and pelvic X-ray exposure history 2.92 （1.88, 4.54）, and dye hair 3.56 （2.01, 6.31）, respectively. Conclusion： Regular consumption of vegetables and good mood are protective factors of premature ovarian failure, there was no significant association among regular consumption of soy products, oral contraceptives and early menarche, and others are risk factors.