附睾管腔酸性微环境的调节机制

Regulation of Luminal Acidification in the Epididymis

精子在睾丸生成之后进入并储存在附睾,附睾管腔内的酸性微环境,使得精子在附睾中维持静息状态和获得受精能力。附睾上皮细胞分布着种类不同的酸碱转运体,参与调节管腔液体HCO3-的重吸收和H+的分泌,从而维持附睾管腔的酸性微环境。

After generation in the testis, the spermatozoa enter and store in the epididymis, where the acidic microenvironment of epididymal tract enable spermatozoa to stay in a immotile state and aquire their fertilizing capacity. Distinct sets of transporters, expressed in specific cell types of the epididymal epithelium, contribute to bicarbonate reabsorption and net proton secretion that occur as the fluid flows through the lumen, therefore maintain the acidic microenvironment in the epididymis.