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体外树突状细胞疫苗策略抗肿瘤免疫治疗研究进展 被引量:2

Study progress about ex vivo dendritic cells therapy for antitumor immunotherapy
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摘要 树突状细胞(DCs)在激活天然的免疫反应和获得性免疫反应中具有独一无二的作用,应用DCs为基础的肿瘤免疫治疗已成为肿瘤治疗的研究焦点。改善DCs疫苗的效能的方法有体外DCs策略和体内DCs策略。本文就体外DCs疫苗策略在肿瘤免疫治疗中的研究进展做一综述。 Because of their unique role in linking the innate and adaptive immune systems,dendritic cells(DCs) have been a logical focus for novel immunotherapies.To augment antitumor immunity of DCs,there are two kinds of strategies: ex vivo DCs therapy and in vivo DCs therapy.This review provides a general overview of ex vivo DCs antitumor immunotherapy and summarizes some of the recent advances in this field.
出处 《中国现代医学杂志》 CAS CSCD 北大核心 2012年第30期49-52,共4页 China Journal of Modern Medicine
基金 国家自然科学基金项目资助(No:81160294)
关键词 树突状细胞 体外DCs策略 肿瘤免疫治疗 dendritic cells ex vivo DCs therapy tumor immunotherapy
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参考文献30

  • 1KOIDO S, HARA E, HOMMA S, et al. Streptococcal preparation OK-432 promotes fusion efficiency and enhances induction of antigen-specific CTL by fusions of dendritic ceils and colorectal cancer cells[J]. J Immunol, 2007, 178(1): 613-622.
  • 2KOIDO S, HARA E, HOMMA S, et al. Dendritic/tumor fusion cell-based vaccination against cancer [J]. Arch Immunol Ther Exp, 2007, 55(5): 281-287.
  • 3谢军平(综述),侯晓华,陶晓南(审校).树突状细胞融合瘤苗在肿瘤免疫中的研究进展[J].国际肿瘤学杂志,2008,35(9):664-667. 被引量:1
  • 4FINN OJ. Cancer vaccines: between the idea and the reality[J]. Nat Rev Immunol, 2003, 3(8): 650-641.
  • 5SCHREIBER TH, RAEZ L, ROSENBLATT JD, et al. Tumor immunogenicity and responsiveness to cancer vaccine therapy: the state of the art[J]. Semin Immunol, 2010, 22(3): 105-112.
  • 6INABA K, INABA M, ROMANI N, et al. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granuloeyte/maerophage colony-stimulating factor[J]. J Exp Med, 1992, 176(6): 1693-1702.
  • 7JONULEIT H, KUHN U, MULLER G, et al. Pro-inflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal calf serum-free conditions[J]. Eur J Immunol, 1997, 27(12): 3135-3142.
  • 8HARRIS KM. Monocytes differentiated with GM-CSF and IL-15 initiate Th17 and Thl responses that are contact-dependent and mediated by IL-15[J]. J Leukoc Biol, 2011, 90(4): 727-734.
  • 9SANTINI SM, LAPENTA C, LOGOZZI M, et al. Type I interferon as a powerful adjuvant for monocyte-derived dendritic cell development and activity in vitro and in Hu-PBL-SCID mice[J]. J Exp Med, 2000, 191(10): 1777-1788.
  • 10ANTONIA S, MULE JJ, WEBER JS. Current developments of immunotherapy in the clinic [J]. Curt Opin Immunol, 2004, 16 (2): 130-136.

二级参考文献22

  • 1Homma S, Kikuchi T, Ishiji N, et al. Cancer immunotherapy by fusion of dendritic and tumor cells and rhIL-12. Eur J Clin Invest, 2005, 35(4) :279-286.
  • 2Koido S, Hara E, Homma S, et al. Streptococcal preparation OK-432 promotes fusion efficiency and enhances induction of antigen-specific CTL by fusions of dendritic cells and colorectal cancer cells. J Immunnol, 2007, 178( 1 ) :613-622.
  • 3Koido S, Hara E, Torii A, et al. Induction of antigen-specific CD4 and CD8 medialed T cell responses by fusion of autologous dendritic cells and metastatic colorectal cancer cells. Int J Cancer, 2005, 117 (4) :587-595.
  • 4Ebert LM, Schaerli P, Moser B. Chemokine-mediated control of T cell traffic in lymphoid and peripheral tissues. Mol Immunol, 2005, 42 (7) :799-809.
  • 5Koido S, Hara E, Homma S, et al. Dendritic/tumor fusion cell- based vaccination against cancer. Arch Immunol Ther Exp, 2007, 55 (5) : 281-287.
  • 6Palucka AK, Dhodapkar MV, Paczesny S, et al. Single injection of CD34 + progenitor-derived dendritic cell vaccine can lead to induction of T- cell immunity in patients with stage Ⅳ melanoma. J Immunother, 2003, 26 (5) :432-439.
  • 7Iinuma T, Homma S, Noda T, et al. Prevention of gastrointestinal tumors based on adenomatous polyposis coli gene mutation by dendritic cell vaccine. J Clin Invest, 2004, 113, (9) : 1307-1317.
  • 8Koido S, Nikrui N, Ohana M, et al. Assessment of fusion cells from patient-derived ovarian carcinoma cells and dendritic cells as a vaccine for clinical use. Gynecol Oncol, 2005, 99(2) :462-471.
  • 9Mukherjee P, Madsen CS, Ginardi AR, et al. Mucin 1-specific immunotherapy in a mouse model of spontaneous breast cancer. J Immunother, 2003, 26( 1 ) :47-62.
  • 10Plunkett T, Graham R, Correa I, et al. Protection against MUC1 expressing mouse tumours by intra-muscular injection of MUC1 cDNA requires functional CD8 + and CD4 + T cells but does not require the MUC1 tandem repeat domain. Int J Cancer, 2004, 109 ( 5 ) : 691- 697.

同被引文献40

  • 1樊建勇,杨慧兰,王颖,关蕾.单纯疱疹病毒2gD-Hsp70融合蛋白基因的构建及表达[J].生物工程学报,2006,22(6):914-918. 被引量:4
  • 2樊建勇,杨慧兰.脂质体包裹HSV-2gD-HSP70融合蛋白诱导小鼠免疫应答的研究[J].中华皮肤科杂志,2007,40(10):609-611. 被引量:1
  • 3Rosenberg SA, Yang JC, Restifo NP. Cancer immunotherapy: moving beyond current vaccines[J]. Nat Med, 2004, 10(9) : 909 -915.
  • 4Palucka AK, Ueno H, Fay J, et al. Dendritic cells : a critical player in cancer therapy[ J]. J Immunother, 2008, 3l(9) : 793 - 805.
  • 5Schueneman AJ, Sugar EA, Uram J, et al. Low total lymphocyte count is associated with poor survival in patients with resected pancreatic adenocarcinoma receiving a GM-CSF secreting pancreatic tumor vaccine [ J ]. Ann Surg Oncol, 2013, 20 ( Suppl 3 ) : $725 - $730.
  • 6Nemunaitis J, Jahan T, Ross H, et al. Phase 1/2 trial of autologous tumor mixed with an allogeneic GVAX vaccine in advanced-stage non-small-cell lung cancer [ J]. Cancer Gene Ther, 2006, 13 (6) : 555 - 562.
  • 7Le DT, Lutz E, Uram JN, et al. Evaluation of ipilimumab in combination with allogeneic pancreatic tumor cells transfected with a GM-CSF gene in previously treated pancreatic cancer [ J ]. J Immunother, 2013, 36 (7) : 382 -389.
  • 8Ishii K J, Akira S. Toll or Toll-bee adjuvant path toward the optimal vaccine development [ J ]. J Clin Immunol, 2007, 27 ( 4 ) : 363 - 371,.
  • 9Yarovinsky F, Kanzler H, Hieny S, et al. Toll-like receptor recognition regulates immunodominance in an antimicrobial CD4^+ T cell response[ J]. Immunity, 2006, 25 (4) : 655 - 664.
  • 10Heit A, Schmitz F, OKeeffe M, et al. Protective CD8 T cell immunity triggered by CpG-protein conjugates competes with the efficacy of live vaccines[J]. J Immunol, 2005, 174(7) : 4373 -4380.

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