摘要
介孔二氧化硅纳米粒(mesoporous silica nanoparticles,MSNs)作为药物载体应用于生物医药领域已成为纳米药剂研究的热点。本文针对在肿瘤诊疗领域的MSNs最新实验设计,重点讨论MSNs载药系统在控制性释放、靶向性输送和克服多药耐药的应用策略。MSNs为肿瘤诊疗药物的传递提供良好的运载平台,具有极大的发展潜力和独特优势。
Mesoporous silica nanoparticles as drug carrier have become the new hot point in the field of biomedical application in recent years.This review focuses on the more recent developments and achievements on experimental design aspect of mesoporous silica nanoparticles with cancer diagnosis and therapy.The key advances of functionalization strategies of mesoporous silica nanoparticles with controlled release,tumor targeting and overcoming multidrug resistance are discussed in particular.Mesoporous silica nanoparticles as unique delivery systems have the potential to provide significantly a sound platform for cancer theranostic application.
出处
《药学学报》
CAS
CSCD
北大核心
2013年第1期8-13,共6页
Acta Pharmaceutica Sinica
基金
国家自然科学基金国际合作与交流项目(81120108013)
国家重点基础研究发展计划(2011CB707700)
国家自然科学基金重点项目(30930028)
关键词
二氧化硅
纳米粒
药物载体
肿瘤
silicon dioxide
nanoparticle
drug carrier
carcinoma
