摘要
Nox(phagocyte-like NADPH oxidase)是吞噬细胞NADPH氧化酶催化亚基gp91phox的一系列同源物,广泛分布于体内多种非吞噬细胞.与NADPH氧化酶类似,Nox激活后可产生ROS,Nox产生的ROS是线粒体外ROS的主要来源.Nox产生的ROS,在控制新陈代谢,调节葡萄糖刺激的胰岛素分泌(glucose-stimulated insulin secretion,GSIS),促使胰岛β细胞凋亡、胰岛功能障碍和糖尿病及其并发症的发生、发展中,发挥着重要作用.调节Nox的活性,改善机体内氧化应激水平,有望成为治疗糖尿病及其并发症的有效新途径.
Nox（phagocytel-ike NADPH oxidase） is the homologs of gp91phox which is the catalytic subunit of the NADPH oxidase. Nox widely exists in various non-phagocytic cells.Like NADPH oxidase,Nox has the ability to generate ROS.ROS derived from Nox,is the major source of extra- mitochondrial ROS in the body.Nox plays a crucial role in many pathological and physiological processes,like regulating metabolism,adjusting GSIS（glucose-stimulated insulin secretion,GSIS）,promoting islet dysfunction,inducing pancreatic β-cell apoptosis,resulting in diabetes and diabetic complications.Modulating the oxidative stress status through regulating Nox activity,is expected to be a new effective way to treat diabetes and diabetic complications.
出处
《中国生物化学与分子生物学报》
CAS
CSCD
北大核心
2013年第1期7-12,共6页
Chinese Journal of Biochemistry and Molecular Biology
关键词
Nox
氧化应激
胰岛Β细胞凋亡
胰岛功能
糖尿病
phagocyte-like NADPH oxidase （Nox）
oxidative stress
pancreatic β-cell apoptosis
isletfunction
diabetes
