脂质体递药系统与奥沙利铂脂质体对结直肠癌治疗的研究

Liposomes delivery system and liposomal oxaliplatin for the treatment of colorectal cancer

奥沙利铂对晚期结直肠癌的临床治疗有较好效果，但有剂量限制性毒性。脂质体作为药物载体，具有缓释性、靶向性和降低药物毒副作用的特点。脂质体的主动靶向修饰对改变抗肿瘤药物的生物分布，减少或逆转肿瘤细胞的多药耐药性，提高抗肿瘤药物的作用也具有意义。利用脂质体的特性，将奥沙利铂制成脂质体治疗结直肠癌有一定意义。

Oxaliplatin is effective for the treatment of advanced colorectal cancer, but its application is restricted because of the doselimiting toxicity. As drug carriers, liposomes are featured with delay release, lesion targeting and they could decrease the side effects of drugs. Active targeting modification of the liposome can change the biological distribution of the anticancer drugs, reduce or reverse multidrug resistance of tumor cells and enhance the effect of antitumor drugs. With these characteristics mentioned above, lipsomes containing oxaliplatin may play an important role in the treatment of colorectal cancer.