CD151和c-Met在大肠癌中的表达及临床意义

Expressions and clinical significances of CD151 and c-Met in colorectal tumors

目的探讨CD151和c-Met在大肠腺癌组织中的表达及其与临床各个病理因素之间的关系。方法应用双重免疫荧光标记法对正常大肠黏膜和大肠腺癌组织各120例进行CD151和c-Met检测,及进行Kaplan-Meier生存分析。采用Spearman等级相关分析CD151和c-Met之间的相关性。结果 CD151大肠正常黏膜和腺癌组织的阳性率分别为21.7%(26/120)、72%(86/120),两者比较具有统计学意义(P<0.001)。c-Met大肠正常黏膜和腺癌组织的阳性率分别为17.5%(21/120)、60%(72/120),腺癌组织与正常黏膜比较具有统计学意义(P<0.001)。在大肠腺癌中,CD151和c-Met的表达与患者年龄、性别和肿瘤的部位、大小无相关性,与肿瘤的分化程度、浸润深度、淋巴结转移及Duke分期有关(P<0.05)。CD151和c-Met在大肠正常黏膜和腺癌组织中的表达经双变量相关分析,Spearman系数r=0.970,表达呈正相关(P<0.001)。CD151+、α3β1+、CD151+α3β1+与大肠癌患者5年生存期密切相关,是影响大肠癌预后的因素(P<0.01、P<0.05、P<0.0001)。结论 CD151和c-Met在大肠癌的表达密切相关。CD151与c-Met联合表达是大肠癌临床预后判断的可靠指标。

Objective To determine the expressions of CD151 and c-Met in colorectal tumors and its clinical significance. Methods The expressions of CD151 and c-Met in 120 specimens of normal colorectal mucosa and 120 specimens of colorectal adenocarcinoma were detected by immunofluorescence double staining method. Patients＇survival was analyzed by Kaplan-Meier method. The correlations of CD151 and c-Met were analyzed by spearman＇s rank correlation. Results In colorectal ad the expressions of CD151 and c-Met was correlated to tumor differentiation, invasion, lymph node metastasis and Duke＇s stage （P 〈0. 05）. In colorectal adenocarcinoma CD151 ex-pression was positively correlated to c-Met expression （ r = 0. 970, P 〈 0. 001 ）. CD151^＋ , α3β1^＋, CD151^＋ α3β1^＋ were closely related with colorectal cancer patients 5-year survival, and were the prognostic factors of colorectal cancer （P 〈 0. 01, P 〈 0. 05, P 〈 0. 0001 ）. Conclusions In colorectal adenocarcinoma, CD151 expression is obviously related to c-Met expression. Co-expression of CD151 and c-Met may be the reliable prognosis indicators of colorectal adenocarcinoma.