肾交感神经消融术临床研究进展

The application of catheter-based renal sympathetic denervation in clinical practice:recent progress in clinical research

近期,肾交感神经消融术(catheter-based renal sympathetic denervation,RDN)的研究成果引起了介入放射学家、血管外科医师的兴趣,亦引起了学术界对肾交感神经在多种疾病发生发展中的用机制亦的重视。此技术不仅为多种以交感神经过度活化为特点的疾病提供了新的治疗方法,也为进一步了解此类疾病的病理生理学研究提供了机会。本文对该技术的研究现状、临床应用、禁忌证、操作步骤、疗效及并发症作一论述。

Recently, the research achievement in catheter- based renal sympathetic denervation technique has greatly attracted the interest of interventional radiologists and vascular surgeons. The academic circles begin to pay more attention to the effect of renal sympathetic nerve activation on the development of various diseases. Catheter-based renal sympathetic nerve ablation provides new therapeutic methods for the disorders that are characterized by excessive sympathetic activation. Moreover, this technique offers certain opportunities for physicians to make researches to further understand the pathophysiology of these diseases. This article aims to make a comprehensive review about the catheter-based renal sympathetic denervation, focusing on its current situation, the clinical application, the contraindications, the operative procedures, the effectiveness, the complications, etc.（J Intervent Radiol, 2013, 22： 001-007）