生物治疗在胃肠道肿瘤应用中的进展

Progress of biotherapy in gastrointestinal carcinomas

胃肠道肿瘤是世界上发病率和死亡率最高的肿瘤之一,尽管近些年传统治疗方法有了很大改进，但晚期胃肠道肿瘤的生存率仍较低。生物治疗已成为继手术、放疗、化疗后的第四种治疗模式，对改善胃肠道肿瘤的预后显示出了良好的应用前景。本文从基因治疗、免疫治疗及分子靶向药物治疗等几方面对近年来生物治疗在胃肠道肿瘤应用中的进展作一综述。

Gastrointestinal carcinomas are among the malignacies with highest morbidity and mortality. The survival rates of these tumors remain pretty low in spite of advancements of traditional treatments. As the fouth treatment method besides surgery, radiotherapy and chemotherapy, biotherapy has shown promising prospect in improving the prognosis of gastrointestinal carcinomas. In this manuscript,we summarized the current progress of biotherapy in gastrointestinal tumors including gene therapy,immune therapy and molecular targeted therapy.