摘要
载脂蛋白A-I(apolipoprotein A-I,APO A-I)作为高密度脂蛋白的重要组成部分,具有维持高密度脂蛋白结构稳定、参与胆固醇逆转运、抗炎和抗氧化的作用。APO A-I水平异常会导致一系列疾病,如:心肌梗死、阿尔茨海默病、遗传性淀粉样变性等。近来研究发现,APO A-I的水平与糖尿病视网膜病变、年龄相关性黄斑变性等眼科疾病密切相关。本文就APO A-I与眼部疾病关系的研究现状进行综述。
Apolipoprotein A-I （APO A-I; is the most important segment of high- density lipoprotein （HDL）, its roles includes possessing structural stability to maintain the structural integrity of HDL,inhibiting atherosclerosis by reversing cholesterol trans- port, playing anti-inflammatory and protecting against oxidative stress. The abnormal level of APO A-I has been identified as a risk factor for some diseases, such as acute myocardial infarction,Alzheimer＇ s disease ,heritage amyloidosis and some eye diseases, et al, Recently,the research shows the abnormal level of APO A-I is obviously correlated with diabetic retinopathy, age-related macular degeneration. This article reviews the re- cent advances in relationship of APO A-I and eye diseases.
出处
《眼科新进展》
CAS
北大核心
2013年第1期88-90,共3页
Recent Advances in Ophthalmology
基金
国家自然科学基金资助(编号:81271046)
北京市自然科学基金资助(编号:7042020)~~
关键词
载脂蛋白A—I
生理功能
眼部疾病
apolipoprotein A-I
physiological function
eye diseases
