多囊卵巢综合征转基因动物模型的研究进展

Transgenic animal model of polycystic ovary syndrome

多囊卵巢综合征(PCOS)是育龄期妇女常见的生殖内分泌及代谢紊乱性疾病,病因不明。建立合适的动物模型对研究其发病机制、病程发展、临床治疗及并发症的预防有着重要的意义。既往的动物模型为雌、雄激素或灯光控制诱导。近年来,转基因动物模型、基因敲除动物及组织特异性基因敲除动物被广泛应用于PCOS的研究。本综述总结了几种通过基因手段复制的啮齿类PCOS动物模型的来源、特点、研究进展、应用及优缺点,为实验研究选择相应的动物模型提供参考。

Polycystic ovary syndrome is the most common endocrinal and metabolic disease in reproductive female.The etiology is still unclear.Building an appropriate animal model will improve the anderstanding of etiology,pathogenesis,clinical strategy and the prevention performance for complication of PCOS.The previous animal models are induced by estrogen,androgen or constant illumination.Recently,new genetically modified animal models,such as transgenic,generalized knock-out or tissue specific knock-out mice were applied in the research of PCOS.The present review summarizes the origin action,features,research progression,application and advantages/disadvantages of several PCOS-like mice,providing optimal model for research.