摘要
真核细胞翻译起始因子5A2(EIF5A2)是EIF5A家族中高度进化保守的基因之一。EIF5A2作为可能的癌基因在多种人类上皮源性肿瘤内呈高表达,并与肿瘤的分期和/或预后不佳相关。EIF5A2通过多种机制诱导肿瘤发生上皮间质转化进而促进肿瘤侵袭转移。EIF5A-MTA1/C-MYC轴可能是上皮源性肿瘤发生侵袭转移的重要调控通路之一。相关分子机制尚需进一步研究。
Eukaryotic translation initiation factor 5A2 gene is a highly conserved gene of EIF5A family.EIF5A2,as a potential oncogene,is highly expressed in a variety of human tumors and associated with the staging and / or poor prognosis of the tumor.EIF5A2 induces epithelial mesenchymal transition through a variety of the mechanisms and thus promotes tumor invasion and metastasis.EIF5A-MTA1/C-MYC axis may be one of the important pathways involved in regulation of tumor invasion and metastasis.The underlying molecular mechanisms need further studies.
出处
《基础医学与临床》
CSCD
北大核心
2013年第1期123-125,共3页
Basic and Clinical Medicine
基金
中国医学科学院北京协和医学院研究生创新基金(X2010028)
