三丁基锡引起的集成式细胞内信号应答反应

Integrated Intracellular Signal Pathways Response Induced by Tributyltin

海洋环境污染物三丁基锡(tributyltin,TBT)引起的细胞内信号通路应答十分复杂,是一种集成式网络反应(integrated network-like intracellular response)。各种细胞因子及它们之间的作用关系构成类似集成电路样网络式分子反应,组成了细胞内一个个相对独立、又互相关联的反应模块。该文综述了TBT引起的细胞内信号通路转导的集成式网络反应现象,旨在为综合评价污染物危害性提供参考。

The intracellular response induced by tributyltin （TBT）, a kind of marine pollutant, is a very complex integrated network-like intracellular response. All the cytokines that participate the intracellular response assembled an ＂integrated circuit＂, in which several both relatively independent and mutually related react modules were formed. The present review focuses on the integrated network-like intracellular response induced by TBT. The purpose of this review is to provide reference for comprehensive evaluation of the harm of environmental pollutants.