13例外耳及中耳恶性肿瘤临床分析

Malignant neoplasm of external auditory canal and middle ear

目的分析外耳及中耳恶性肿瘤的类型、治疗方法及疗效。方法回顾性分析北京大学第一医院1993年至2010年经治的13例外耳及中耳恶性肿瘤患者的临床表现和手术结果。其病理类型分别为鳞状细胞癌8例,腺癌3例,神经内分泌癌1例,恶性黑色素瘤1例。3例行单独手术治疗,8例行手术治疗联合术后放射治疗,2例行放、化疗。结果全组总5年生存率60%,手术或综合治疗者5年生存率为75%,切缘阳性者5年生存率为40%。结论对外耳道及中耳恶性肿瘤的患者采取手术或综合治疗可提高生存率,术后病理切缘阳性可能是预后不良的因素。

Objective To evaluate the treatment and outcomes of malignant neoplasms involving the temporal bone. Methods Thirteen cases of malignant neoplasms in external auditory canal and middle ear treated from 1993 to 2010 were reviewed retrospectively for their clinical characteristics and treatment outcomes. Three cases were treated with surgery alone, and 8 cases were given combined treatment of surgery and chemo- and radiotherapy. Two patients received only chemo- and radiotherapy. Results The 5-year accumulative survival rates were 60%. The 5-year survival rate in patients who received combined treatment were 75%, the 5-year survival rate in the cases with positive pathology margin were 40%. Conclusions In patients with malignant tmnors of the external auditory canal and middle ear, combined treatment is an ef- fective management. Positive pathology margin may indicate poor prognosis.