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多巴胺β羟化酶基因多态性和首发精神分裂症的关联分析 被引量：2

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摘要 有研究发现多巴胺和肾上腺素异常在精神分裂症发病机制中起重要作用[1]。多巴胺β羟化酶（dopaminebeta-hydroxy-lase，DBH）是催化多巴胺向去甲肾上腺素转化的核心酶[2]。
作者 惠李 杜伟利 陈大春 张保华 王志仁 修梅红 王帆 张向阳 张萱
机构地区 上吉林大学公共卫生学院基因组医学研究中心、卫生部放射生物学重点实验室 吉林大学第二医学院糖尿病合并症研究中心 北京回龙观医院精神医学研究中心
出处 《中国神经精神疾病杂志》 CAS CSCD 北大核心 2012年第12期715-715,719,723,728,共4页 Chinese Journal of Nervous and Mental Diseases
基金 吉林大学研究生创新基金(编号:20121113) 国家自然基金(编号:81171064)
关键词 首发精神分裂症 多巴胺β羟化酶基因多态 性病例对照
分类号 R749.3 [医药卫生—神经病学与精神病学]
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参考文献8

  • 1Davis KL,Kahn RS,Ko G. Dopamine in schizophrenia:a review and reconceptualization[J].American Journal of Psychiatry,1991,(11):1474-1486.
  • 2Kemper CM,O'Connor DT,Westlund KN. Immunocvtochemical localization of dopamine beta hydroxylase in neurons of the human brain stem[J].Neuroscience,1987,(03):981-989.
  • 3Cubells JF,van Kammen DP,Kelley ME. Dopamine beta-hydroxylase:two polymorphisms in linkage disequilibrium at the structural gene DBH associate with biochemical phenotypic variation[J].Human Genetics,1998,(05):533-540.doi:10.1007/s004390050736.
  • 4Yamamoto K,Cubells JF,Gelemter J. Dopamine betahydroxylase(DBH)gene and schizophrenia phenotypic variability:a genetic association study[J].American Journal of Medical Genetics Part B:Neuropsychiatric Genetics,2003,(01):33-38.
  • 5Park JK,Kim JW,Lee HJ. Dopamine beta-hydroxylase gene polymorphisms and psychotic symptoms in schizophrenia[J].Am J Med Genet B Neuropsychiatr Geneti,2007,(07):944-945.
  • 6Cubells JF,Kranzler HR,McCance-Katz E. A haplotype at the DBH locus,associated with low plasma dopamine beta-hvdroxvlase activity,also associates with cocaine-induced paranoia[J].Molecular Psychiatry,2000,(01):56-63.
  • 7Zhang XY,Chen DC,Xiu MH. Association of functional dopamine-beta-hydroxylase (DBH) 19 bp insertion/deletion polymorphism with smoking severity in male schizophrenic smokers[J].Schizophrenia Research,2012,(01):48-53.
  • 8Zabetian CP,Anderson GM,Buxbaum SG. A quantitative-trait analvsis of human plasma-dopamine beta-hydroxvlase activity:evidence for a major functional polymorphism at the DBH locus[J].American Journal of Human Genetics,2001,(02):515-522.

同被引文献25

  • 1张志强,王向东,杨新蓉.文拉法辛治疗精神分裂症患者认知功能障碍的疗效[J].临床精神医学杂志,2005,15(1):43-43. 被引量：4
  • 2Malhotra P.A,Parton A.D,Greenwood R,Husain M,周永.视觉忽略患者空间感知的去甲肾上腺素能调节[J].世界核心医学期刊文摘（神经病学分册）,2006,2(5):8-8. 被引量：1
  • 3Lindenrmyer JP, Harvey PD, Khan A, et al. Schizophrenia: measurements of Psychopathology Psychiatry[ J ]. Clin North Am, 2007, 30:339 - 363.
  • 4Medalia A, Lim R. Treatment of cognitive dysfunction in psychiatric disordersp[ J]. J Psychiatr Pract, 2004, 10( 1 ) : 17 - 25.
  • 5Piskulic D, Olver JS, NormanTR, et al. Behavioural studies of spatial working memory dysfunction in schizophrenia: a quantitative literaturereview[ J]. Psychiatry Res, 2007, 150 (2) :111 -121.
  • 6Elliott R. Executive function and their disorders. Imaging neuroscience : Clinical frontiers for diagnosis and management [J]. Br Med Bull, 2003, 65:49 -59.
  • 7Tanaka T, Tomotake M, Ueoka Y, et al. Clinical correlates associated with cognitive dysfunction in people with schizophrenia [ J ]. Psychiatry Clin Neurosci, 2012, 66 (6) : 491 -498.
  • 8Bralet MC, Navarre M, Eskenazi AM, et al. Interest of a new instrument to assess cognition in schizophrenia: The Brief Assessment of Cognition in Schizophrenia (BACS) [ J ]. Encephale, 2008, 34 (6) :557 - 562.
  • 9Tarbox SI, Pogue-Geile MF. Development of social functioning in pre-schizophrenia children and adolescents:a systematic review [ J ]. Psychol Bull, 2008, 134 : 561 - 583.
  • 10Hui L, Zhang X,Yu YQ, et al. Association between DBH 19bp insertion/deletion polymorphism and cognition in first-episode schizophrenic patients [ J ]. Schizophr Res, 2013,147 (2 - 3 ) :236 - 240.

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中国神经精神疾病杂志
2012年 第12期

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