组织工程化软骨构建的研究进展

Research advances in construction of tissue-engineered cartilage

背景:组织工程学方法为关节软骨缺损的修复提供了新的治疗模式,具有广阔的应用前景。目的:探究组织工程化软骨的构建方法、研究方向和应用前景。方法:检索中国期刊全文数据库(CNKI:1991至2011年)和WebofScience(1991至2011年)数据库,检索词分别为"组织工程,软骨损伤,种子细胞,支架"和"TissueEngineering,CartilageDefects,SeedCell,Scaffolds",语言分别设为中文和英文。阅读文题和摘要进行筛选,选择具有原创性,论点论据可靠且分析全面,密切相关的文章,排除重复性研究以及质量较差文章。按纳入排除标准筛选后,共纳入30篇文章。结果与结论:组织工程化软骨多以各种种子细胞与不同的支架材料进行复合,且在软骨缺损修复中体现了较好的应用价值,但应用于临床还有许多具体问题需要解决。

BACKGROUND：Tissue engineering method provides a new treatment for repair of articular cartilage defects,which has broad application prospects.OBJECTIVE：To explore the methods,researches and application prospects of the tissue-engineered cartilage construction.METHODS：A computer-based online search of China Journal Full-text Database and Web of Science was performed for articles and reviews in Chinese and English from 1991 to 2011.The key words were ＂tissue engineering,cartilage defects,seed cell,scaffolds＂ in Chinese and English.By Screening reading titles and abstracts,relevant literatures were included.Repetitive articles with poor quality were excluded.Finally,30 articles were included.RESULTS AND CONCLUSION：Tissue-engineered cartilage with a variety of seed cells loaded composite scaffolds has made a great progress and shown a good role in repair of cartilage defects,but there are some specific problems to be solved in clinic.