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Notch1受体在乳腺癌组织中的表达及其与临床病理特征的关系 被引量：1

The expression of Notch1 receptor in breast cancer and the relation with clinical pathological characteristics
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摘要 目的探讨Notch1受体与乳腺癌患者的临床病理特征及预后的关系。方法应用免疫组化技术检测106例乳腺癌组织中Notch1受体、ER、PR、CerbB-2受体表达情况,分析其与临床病理特征及预后的相关性。结果乳腺癌组织中Notch1受体表达明显高于癌旁正常组织(P<0.05);Notch1受体表达与CerbB-2具有相关性(P<0.05),与ER、PR无显著相关性(P>0.05);Notch1受体高表达组5年生存率低于低表达组(P<0.05)。结论乳腺癌组织中Notch1受体表达明显高于癌旁正常组织;Notch1受体表达与CerbB-2具有相关性,推测Notch1受体可能与CerbB-2存在交互作用;Notch1受体高表达与预后不良有关。 Objective To explore the relationship between Notchl receptor and the clinical pathological characteristics and prognosis of breast cancer. Methods In 106 cases of breast cancer, immunohistochemieal staining method were used to detect the expression of Notchl receptor, ER, PR, and CerbB-2 in the breast cancer tissue samples, then analyse the relationship between Notchl receptor and clinical pathological characteristics and prognosis of breast cancer. Results The expression of notch1 receptor in breast cancer is higher than that of the normal breast tissue （P〈0.05）. There was a significant association of Notchl receptor with CerbB-2（P〈0.05）. The 5 years survival rate of breast cancer patients with high Notchl receptor is lower than patients with low Notchl receptor. Conclusion The expression of Notchl in breast cancer is higher than that of the normal breast tissue.The expres- sion of Notchl is associated with CerbB-2.High Notchl receptor is associated with poor prognosis.
作者 李芳华 张新民
机构地区 中南大学湘雅二医院肾内科
出处 《解剖学研究》 CAS 2012年第6期432-435,共4页 Anatomy Research
基金 湖南省"十一五"重点学科建设专项经费(湘财教指【2011】90号)
关键词 乳腺癌 Notch1受体 CERBB-2 预后 Breast cancer Notchl receptor CerbB-2 Prognosis
分类号 R737.9 [医药卫生—肿瘤]
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参考文献10

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共引文献205

同被引文献24

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解剖学研究
2012年 第6期

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