期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

不同剂量辛伐他汀对急性冠脉综合征患者超敏C反应蛋白和细胞间黏附分子-1的影响 被引量：9

下载PDF
导出
摘要 目的探讨不同剂量辛伐他汀对急性冠脉综合征(ACS)患者超敏C反应蛋白(hs-CRP)和细胞间黏附分子-1(ICAM-1)的影响。方法将本院心内科住院的ACS患者81例随机分为A组、B组和C组,各27例。3组均行ACS常规治疗,在此基础上,A组给予辛伐他10mg/d,B组给予辛伐他汀20mg/d,C组给予辛伐他汀40mg/d,均每晚口服1次,连续治疗2周。观察治疗前后3组患者的血脂变化、血清hs-CRP和ICAM-1的变化。结果治疗后3组患者血清三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)比较,差异均有统计学意义(P<0.05)。治疗后3组血清hs-CRP和ICAM-1比较,差异均有统计学意义(P<0.05);B组和C组血清hs-CRP和ICAM-1与A组比较,差异有统计学意义(P<0.05);C组血清hs-CRP和ICAM-1与B组比较,差异有统计学意义(P<0.05)。结论辛伐他汀等他汀类药物可通过降低ACS患者的血清hs-CRP和ICAM-1等促炎性细胞因子的水平,减轻ACS患者粥样斑块内的炎症。辛伐他汀剂量的升高,其抗感染作用越显著。
作者 蓝海东
机构地区 广西柳州钢铁(集团)职工医院
出处 《实用心脑肺血管病杂志》 2013年第1期18-19,共2页 Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词 辛伐他汀 急性冠状动脉综合征 C反应蛋白 细胞间黏附分子
分类号 R541.4 [医药卫生—心血管疾病]
  • 相关文献

参考文献8

二级参考文献17

  • 1刘颖.他汀类血脂调节药的临床应用[J].中国基层医药,2006,13(1):161-162. 被引量：19
  • 2李卫萍,贾三庆,顾复生.急性冠脉综合征中妊娠相关血浆蛋白A与高敏C反应蛋白的相关性研究[J].中国现代医学杂志,2007,17(3):305-308. 被引量：15
  • 3张志辉,李旭平,杨侃.辛伐他汀对冠心病人丙二醛化低密度脂蛋白、妊娠相关蛋白酶-A的影响[J].中华高血压杂志,2007,15(2):110-114. 被引量：6
  • 4Apple FS, Wu AH, Mair J, et al. Future biomarkers for detection of ischemia and risk stratification in acute coronary syndrome[J]. Clin Chem, 2005,51:810-824.
  • 5Trepels T, Zeiher AM, Fichtlscherer S. Acute coronary syndrome and inflammation biomarkers for diagnostics and risk stratification[J]. Herz, 2004,29:769-776.
  • 6Heeschen C, Dimmeler S, Hamm CW, et al. Pregnancy-associated plasma protein-A levels in patients with acute coronary syndromes: comparison with markers of systemic inflammation, platelet activation, and myocardial necrosis[J]. J Am Coll Cardiol, 2005,45:229-237.
  • 7Sacks FM. Lipid-lowering therapy in acute coronary syndromes[J].JAMA,2001, 285:1758-1760.
  • 8Mueck AO,Seeger H,Risch M,et al.Further evidence for direct vascular actions of statins:effect on endothelial nitric oxide synthase and adhesion moldcules[J].Exp Clin Endocrinol Diabetes,2001,109:181-183.
  • 9Lawrence JB, Oxvig C, Overgaard MT, et al. The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-A[J]. Proc Natl Acad Sci U S A, 1999, 96:3149-3153.
  • 10Plenge JK,Hernandez TL,Weil KM,et al.Simvastatin lowers C-reactive protein within 14days:an effect independent of low-density lipoprotein cholesterol reduction[J]. Circulation,2002,106:1447-1452.

共引文献146

同被引文献92

  • 1曹雅旻,胡大一.辛伐他汀对巨噬细胞基质金属蛋白酶-2、9表达及分泌的影响[J].中华心血管病杂志,2004,32(7):640-642. 被引量：21
  • 2Ramunni A, Brescia P, Dambra P, et al. Effect of Low-Density Lipoprotein Apheresis on Circulating Endothelial Progenitor Cells in Familial Hypercholesterolemia. Blood Purif,2010,29: 383-389.
  • 3Deschaseaux F, Selmani Z, Falcoz PE, et 81. Two types of circulat- ing endothelial progenitor cells in patients receiving long term thera- py by HMG-CoA reductase inhibitors. European Journal of Pharma- cology,2007,562(1-2) : 111-118.
  • 4Dimmeler S, Aicher A, Vasa M, et al. HMG-CoA reductase inhibi- tors(statins) increase endothelial progenitor cells via the Pl3-kinase /Akt pathway. J Clin Invest,2001,108 (3) : 391-397.
  • 5NachtigalP, KopeckyM, SolichovaD, et al. The changes in the en- dothelial ex-pression of cell adhesionmolecules and iNOS in the ves- selwall after the short-term administration of simvastatin in rabbit model of athemsclerosis. JPharm Pharmacol,2005, 57 : 197-203.
  • 6Pasterkamp G, Schoneveld AH, Van der Wal AC, et al. Inflamma- tion of the atherosclerotic cap and shoulder of the plaque is a com- mon and locally observed feature in unruptured plaque of femoral and coronary arteries. Arterioscler Thromb Vasv Bid,1999,19( 1 ) : 54.
  • 7lnoue T, Node K. Statintherapy for viseular, failure. Cardiovszc DrugsTher,2007,21 (4) : 281-295.
  • 8Undas A, Brummel-Ziedins KE, Potaezek DP, et al. Atorvastatin and quinaprilinhibit blood coagulation in patients with coronary ar- tery dis-ease following 28 days oftherapy. J Thromb Haemost, 2006, 4 ( 11 ) :2397-2404.
  • 9Kaneyuki U, Ueda S, Yamagishi S, et aL Pitavastatin inhibits-57- Lysophosphatidicacid-induced proliferation and monocyte chemoat- traetant protein-I expression inaortie smooth muscle cells by sup- pressing Rac 1-mediated reactive oxygen spe. cies generation. Vase Phannacol, 2007, 46(4) :286-292.
  • 10Kinlay S, Egido J. Inflammatory biomarkers in stable atheroselero- sis. Am J Cardiol, 2006, 98:2-8.

引证文献9

二级引证文献65

实用心脑肺血管病杂志
2013年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部