颈动脉粥样硬化斑块性质与外周血炎性因子标志物的关系

Relationship between atherosclerotic plaque character and inflammatory factor tumor markers inperipheral blood

目的探讨颈动脉粥样硬化斑块性质与外周血炎性因子的关系。方法112例经颈动脉彩色多普勒超声检测的颈动脉粥样硬化患者，分为不稳定斑块组63例和稳定斑块组49例；分别检测外周血基质金属蛋白酶9（MMP-9）、超敏C反应蛋白（hs-CRP）、白细胞介素18（IL-18），人巨细胞病毒．PP65抗原的浓度，并进行统计学分析。结果不稳定斑块组与稳定斑块组相关炎性因子MMP-9[（235．47±29．28）、（137．28±61．03）ng／L，t=2．716，P〈0．01]、hs—CRP[（401．20±10．58）、（269．20±35．75）μg／L，t=2．809，P〈0．01]、IL-18[（175．56±19．68）、（91．37±11．58）ng／L，t=2．135，P〈0．05]比较差异有统计学意义；人巨细胞病毒-PP65抗原阳性率分别为30．15％（19／63）与14．29％（7／49），两组比较差异有统计学意义（X^2=3．90，P〈0．05）。结论动脉斑块不稳定性与炎症因子的增高有关，炎性反应可使动脉硬化斑块不稳定，进一步引起急性缺血性脑血管病的发生。

Objective To study the relationship between carotid atherosclerotic plaque character and inflammatory factor tumor marker in peripheral blood. Methods A total of 112 carotidatherosclerosis patients diagnosed with carotid artery color Doppler ultrasonic were divided into astable plaque group（ n = 63 ） and stable plaque group （ n = 49 ）. The level of matrix metalloproteinase-9 （ MMP-9 ）, high-sensitivity C-reactive protein （ hs- CRP） ,iuterleukin -18 （ IL-18 ）, human cytomegalovirus-PP65 （ HCMV-PP65 ） antigen in peripheral blood were determined and compared between these two groups. Results There were significant differences on the level of MMP-9 （ （235.47 ± 29. 28 ） ng/L vs （ 137.28 ± 61.03 ） ng/L, t = 2. 716, P 〈 0.01 ）, hs-CRP（ （401.20 ± 10. 58 ）μg/L vs （269.20±35.75）μg/L,t=2.809,P〈0. 01）,IL-18 （（175.56 ±19.68）ng/L vs （91.37±11.58） ng/L,t =2. 135, P 〈0.05） and positive rate of HCMV-PP65 antigen（30. 15% （19/63） vs 14. 29% （7/49）, X^2= 3.90, P 〈 0. 05 ） between astable plaque group and stable plaque group. Conclusion Carotid atherosclerotic plaque instability is related with increased level of inflammatory factors. Inflammatory reaction may increase the instability of atherosclerotic plaque and further cause the occurrence acute ischemic cerebrovascular disease.