保肛术联合放、化疗对低位或超低位中晚期直肠癌的临床疗效

The clinical effect of combination of anus preservation operation radiotherapy and chemotherapy to medialand late stage colorectal cancer

目的探讨保肛术联合放、化疗对低位或超低位中晚期直肠癌的临床疗效。方法 2006年8月至2010年12月在我院行保肛术的低位或超低位直肠癌患者56例(保肛手术组),以及同期行Miles手术的直肠癌患者64例(Miles手术组),比较两组患者术中、术后一般情况以及随访两年复发和死亡情况。结果保肛手术组手术时间、术中出血量和住院时间均显著低于Miles手术组,差异具有统计学意义,P<0.05;而两组间术后排气时间及术后留置导尿管时间差异无统计学意义,P>0.05。保肛手术组2年后复发率为14.3%,死亡率为23.2%,Miles手术组复发率为14.1%,死亡率为23.4%,两组相比,差异均无统计学意义,P>0.05。结论保肛手术联合放、化疗可以显著提高低位或超低位中晚期直肠癌患者的生活质量,并且近期疗效和远期疗效与Miles手术并无差异。

Objective To investigate the clinical effect of combination of anus preservation operation, radiotherapy and chemotherapy to medial and late stage colorectal cancer. Methods 56 medial and late stage colorectal cancer patients who chosed combination of anus preservation operation, radiotherapy and chemotherapy were enrolled from August 2006 to December 2010, 64 patients who chosed miles operation were enrolled at the same time. The situation of intraoperation and postoperation, reappear and death in two years were compared. Results The operating time, blood loss and operation hospital stay in anus preservation operation were lower than in miles operation,P0.05.but time of postoperative exhaust and urethral catheter in patients were no difference in two groups,P0.05.After two years follow-up, we found that the reappearing rate and mortality were 14.3%, 23.2% in anus preservation operation and 14.1%, 23.4% in miles operation ,there was no differences in two groups, P0.05.Conclusion Combination of anus preservation operation, radiotherapy and chemotherapy can improve the quality of life in medial and late stage colorectal cancer patients. There were no differences of short-term curative effect and the long-term outcome in two operation ways.