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缝隙连接——心房颤动药物治疗的下一个靶点 被引量：2

Gap junction the next target of drug therapy on atrial fibrillation
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摘要 心房颤动（房颤）是最常见的一类室上性心律失常。它既见于有基础心脏病变的患者，也见于无任何临床病变的患者。随着老龄化社会的到来，房颤的发病率、致残率及病死率不断攀升，已成为令人关注的公众健康问题。
作者 郑良荣 张必祺
机构地区 浙江大学医学院附属第一医院心内科
出处 《中华心律失常学杂志》 2012年第6期422-423,435,共3页 Chinese Journal of Cardiac Arrhythmias
关键词 心房颤动 药物治疗 缝隙连接 室上性心律失常 靶点 老龄化社会 心脏病变 临床病变
分类号 R541.75 [医药卫生—心血管疾病]
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参考文献28

  • 1Schotten U, Verheule S, Kirchhof P, et al. Pathophysiological mechanisms of atrial fibrillation:a translational appraisal. Physiol Rev, 2011,91:265-325.
  • 2Unger VM, Kumar NM, Gilula NB, et al. Three dimensional structure of a recombinant gap junction membrane channel. Science, 1999,283 : 1176-1180.
  • 3van Veen TA, van Rijen HV, Jongsma HJ. Physiology of cardiovascular gap junction. Adv Cardiol,2006,42 : 18-40.
  • 4Spach MS, Starmer CF. Mtering the topology of gap junctions a major therapeutic target for atrial fibrillation. Cardiovasc Res, 1995, 30:337-344.
  • 5Chou CC, Chen PS. New concepts in atrial fibrillation: neural mechaniam and calcium dynamics. Cardiol Clin,2009 ,27 :35-43.
  • 6Chen Y J, Chen YC, Yeh HI, et al. Electrophysiology and arrhyth- mogenic activity of single cardiomyocytes from canine superior vena cava. Circulation, 2002,105 : 2679 -2685.
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  • 9Zhang W, Ma X, Zhong M, et al. Role of the calpain system in pulmonary vein connexin remodeling in dogs with atrial fibrillation. Cardiology ,2008,112:22-30.
  • 10Yeh HI, Lai YJ, Lee SH, et al. Remodeling of myocardial sleeve and gap junctions in canine superior vena cava after rapid pacing. Basic Res Cardiol,2006,101:269-280.

同被引文献23

  • 1赵红,李海涛,顾定伟,李丽华.口服小剂量螺内酯抗高血压大鼠心肌纤维化[J].中华老年心脑血管病杂志,2007,9(10):693-695. 被引量：4
  • 2OLIVEIRA M I,DA SILVA N,CUNHA P,et al.Effect of acute autonmic modulation on atrial aonduction delay and local electrograms duration in paroxysmalatrial fibrillation[J].Int J Cardiol,2011,149:290-295.
  • 3KIRCHHOF P,FABRITZ L.Of hammers and screws:rennin-angiotensin-aldosterone system inhibition to prevent atrial fibrillation in patients with hypertension[J].Eur Heart J,2014,35:1169-1171.
  • 4JANUARY C T,WANN L S,ALPERT J S,et al.2014AHA/ACC/HRS guideline for the management of patients with atrial fibrillation:executive summary[J].Circulation,2014,130:2071-2104.
  • 5MARCELO P B,LUDIMILA F,ELIS A S,et al.Long-term use of low-dose spironolactone inspontaneously hypertensive rats:Effects on left ventricular hypertrophy and stiffness[J].Phamacological Report,2011,63:975-982.
  • 6KIMURA S,ITO M,TOMITA M,et al.Role of mineralocorticoid receptor on atrial structural remodeling and inducibility of atrial fibrillation in hypertensive rats[J].Hypertens Res,2011,34:584-591.
  • 7COZMA D,KALIFA J,LIGHEZAN D,et al.Mechanism of atrial fibrillation:decremental conduction,fragmentation,and ectopic activity in patients with drug resistant paroxysmal atrial fibrillation and structurally normal heart[J].Pacing Clin Electrophysiol,2005,Suppl 1:S115-119.
  • 8ASHISH P,DIVYANG P,MCTIERNAN C F,et al.Relaxin suppresses atrial fibrillation by reversing fibrosis and myocyte hypertrophy,and increasing conduction velocity and sodium current in spontaneously hypertensive rat hearts[J].Circ Res,2013,113:313-321.
  • 9PEREIRA L M,MANDARIM-DE-LACERDA C A.Myocardial changes after spironolactone in spontaneous hypertensive rats.A laser scanning confocal microscopy study[J].J Cell Mol Med,2002,6:49-57.
  • 10EFREMIDIS M,SIDERIS A,PRAPPA E,et al Effect of atrial pressure increase on effective refractory period and vulnerability to atrial fibrillation in patients with lone atrial fibrillation[J].J Interv Card Electrophysiol,1999,3:307-310.

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中华心律失常学杂志
2012年 第6期

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