奎硫平和利培酮治疗老年期痴呆患者精神行为症状对照研究

Comparative study of quetiapine and risperidone in the treatment of patients with senile dementia accompanied with psychiatric symptoms

目的:探讨奎硫平和利培酮治疗老年期痴呆患者的精神行为症状疗效及不良反应。方法:对64例老年痴呆患者随机分为奎硫平组和利培酮组进行治疗,疗程8周。采用阿尔茨海默病病理行为评定表(BEHAVE-AD)及治疗中出现的症状量表(TESS)评定疗效和不良反应。结果:奎硫平组对精神行为症状的有效率93.7%,利培酮组90.6%,两组无显著性差异(P>0.05),不良反应少。结论:奎硫平和利培酮对老年期痴呆伴发的精神行为障碍患者安全有效,适合临床使用。

Objective：To evaluative and compare the efficacy and adverse effects of puetiapine and risperidone.in the treatment of patients with senile dementia accompanied with psychiatric symptoms.Methods：64 patients with senile dementia were randomly divided into quetiapine group and risperidone group for 8 weeks therapy.Behavioral pathology in Alzhimer＇s disease rating scale（BEHAVE-AD） was used to access the efficacy and treatment emergent symptoms scale（TESS） was used to evaluate the adverse effects.Results：Both quetiapine and risperidone provided progressive importovement in patients with senile dementia accompanied with psychiatric symptoms,93.7% for quetiapine group and 90.6% for risperidone group and they both have less adverse effects.Conclusion：Quetiapine was effective and safe in treatment of patients with senile dementia and was suitable for clinical use.