异丙酚、硫喷妥钠预防气管插管危险性的临床随机对照研究

Effects of propofol compared to thiopentone on preventing riskiness of tracheal intubation

目的比较异丙酚与硫喷妥钠预防气管插管危险性的效果。方法选择全麻气管插管手术病人 ２２４例，观察异丙酚 ２．０ｍｇ／ｋｇ复合芬太尼 ２μｇ／ｋｇ的气管插管危险性，并采用多因素分析与硫喷妥钠 ５．０ｍｇ／ｋｇ复合芬太尼 ２μｇ／ｋｇ进行比较。结果硫喷妥钠组不满意率为 ８５．５９％，异丙酚组为８１．４２％，组间无显著性差异（Ｐ＞０．０５），除外低血压症，硫喷妥销组不满意率为７９．２８％，异丙酚组为４５．１３％组间有显著性差异（Ｐ＜０．０１）；硫喷妥钠组危险率为３６．０４％，异丙酚组为１７．７０％两组间有显著性差异（Ｐ＜０．０１）。结论异丙酚预防气管插管危险性的临床效果比硫喷妥钠具有一定的优越性，但异丙酚的低血压发生率比硫喷妥钠明显增高。

Objective To compare the effects of propofol with thiopentone on preventing riskiness of tracheal intubation. Methods In 224 elective surgical patients under general anesthesia, the riskiness of tracheal intubation was evaluated following the administration of fentanyl 2μg/kg combined with propofol 2.0mg/kg (group P) or thiopentone 5.0 mg/kg (group T) respectively, with multivariate analysis. Results Risk rate was 36. 04 % in group T and 17. 70 % in group P (P < 0. 01 ), and unsatisfactory rate was 79. 28 % in group T and 45. 13 % in group P (P < 0. 01 ) if hypotension was unconcerned. No significant difference in general unsatisfactory rate (85. 59% in group T, 81 .42% in group P) was found (P > 0 .05). Conclusions There is certainly clinical advantage of propofol compared to thiopentone in terms of preventing riskiness of tracheal intubation if hypotension of propofol is unconcerned.