摘要
Objective To evaluate possible clinical effects of adiponectin, resistin, 1L-6, and TNF-a in obese and non-obese patients with polycystic ovary syndrome （PCOS）. Methods Seventy selected PCOS patients were recruited for this study, and were divided into two groups based on their body mass index （BM1）： 35 obese （BM1 25 kg/m2, group A）, 35 non-obese （BMI〈25 kg/me, group B）. In addition, 35 healthy non-obese women （BMI〈25 kg/m2） were enrolled as the control （group C）. Serum levels of FSH, LH, T, glucose, insulin, adiponectin, resistin, 1L-6, TNF-a. were detected, and compared the differences of them among three groups. Results Blood glucose levels among three groups had no difference （P〉0.05）. Blood insulin level was significantly greater in group A than in group B or group C （P〈0.05）, and a significant difference existed between group B and group C （P〈0. 05）. The ratio of glucose/insulin was significantly higher in group A than in group B or group C （P〈0.05）, and the ratio in group B was significantly higher than that in group C （P〈0.05）. Adiponectin level was significantly lower and resistin level was significantly higher in group A than in group B or group C （P〈0.05）. IL-6 level in group C was significantly lower than that in group A or group B （P〈0.05）, and significant difference was found between group A and group B （P〈0.05）. TNF-a level was a slight high in group B, whereas there was no statistical difference among three groups （P〉0.05）. Conclusion Disturbances of some metabolic and inflammatory adipokines could involve the pathogenesis of PCOS in both obese and non-obese women. Low-grade chronic inflammation might have negative effects on the development of PCOS in non- obese women.
Objective To evaluate possible clinical effects of adiponectin, resistin, 1L-6, and TNF-a in obese and non-obese patients with polycystic ovary syndrome （PCOS）. Methods Seventy selected PCOS patients were recruited for this study, and were divided into two groups based on their body mass index （BM1）： 35 obese （BM1 25 kg/m2, group A）, 35 non-obese （BMI〈25 kg/me, group B）. In addition, 35 healthy non-obese women （BMI〈25 kg/m2） were enrolled as the control （group C）. Serum levels of FSH, LH, T, glucose, insulin, adiponectin, resistin, 1L-6, TNF-a. were detected, and compared the differences of them among three groups. Results Blood glucose levels among three groups had no difference （P〉0.05）. Blood insulin level was significantly greater in group A than in group B or group C （P〈0.05）, and a significant difference existed between group B and group C （P〈0. 05）. The ratio of glucose/insulin was significantly higher in group A than in group B or group C （P〈0.05）, and the ratio in group B was significantly higher than that in group C （P〈0.05）. Adiponectin level was significantly lower and resistin level was significantly higher in group A than in group B or group C （P〈0.05）. IL-6 level in group C was significantly lower than that in group A or group B （P〈0.05）, and significant difference was found between group A and group B （P〈0.05）. TNF-a level was a slight high in group B, whereas there was no statistical difference among three groups （P〉0.05）. Conclusion Disturbances of some metabolic and inflammatory adipokines could involve the pathogenesis of PCOS in both obese and non-obese women. Low-grade chronic inflammation might have negative effects on the development of PCOS in non- obese women.
基金
supported by the Fundamental Research Funds for the Central Universities,China(No.21612445)
