晚期肝硬化合并真菌感染临床分析

The advanced cirrhosis fungal infection clinical analysis

目的分析晚期肝硬化合并真菌感染的临床特点和治疗方法。方法采用回顾性调查方法对30例晚期肝硬化合并真菌感染患者的临床资料以及相关因素进行整体分析。结果 30例患者中,病发真菌感染以深部感染为主,其中,感染部位以肠道为主,占50.4%;其次是口腔感染,占12.3%、下呼吸道占16.2%,腹腔占8.2%、泌尿道占7.9%和血液占5.0%;感染菌种主要以曲霉菌及白色念珠菌为主;在30例晚期肝硬化合并真菌感染的患者中,85%的患者有侵袭性操作、广谱抗生素以及各种免疫剂的使用。30例患者中,合并医院真菌感染者中死亡的25例,占83.3%,与真菌直接相关的有3例,使用抗生素的效果相对较差,预后不良而且病死率也比较高。结论晚期肝硬化合并真菌感染预后差,病死率相对较高,应该采取多种综合措施,积极预防,加强护理措施的运用。

Objective To analyze the clinical characteristics and treatment of advanced cirrhosis fungal infection. Methods A retrospective survey of 30 patients with advanced cirrhosis of fungal infections in patients with clinical data as well as the relevant factors to the overall analysis. Results In 30 patients, the incidence of fungal infections mainly to deep infection, including the site of infection intestinal dominated, accounting for 50. 4% ; followed by oral infection, accounting for 12. 3% of the lower respiratory tract （ 16. 2% ）, accounted for 8. 2% of the abdominal cavity urinary tract accounted for 7. 9% and accounted for 5. 0% of the blood; infected bacteria mainly Aspergillus and Candida albicans; invasive operation in 30 patients with advanced cirrhosis with fungal infections in patients, 85% of patients, broad-spectrum the use of antibiotics, and a variety of immune a- gents. 30 patients, the merging hospitals fungal infection who died in the 25 cases, accounting for 83. 3%, three cases are directly related with the fungus, the effect of the use of antibiotics is relatively poor, poor prognosis and high mortality. Conclusion Of advanced cirrhosis fungal infection and poor prognosis, the fatality rate is rela- tively high, should take comprehensive measures to actively prevent the use of enhanced care measures.